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Public Health Genomics and Precision Health Knowledge Base (v9.0)
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Precision Health Database|Search|Public Health Genomics and Precision Health Knowledge Base (PHGKB)
Last data update: Apr 25, 2024
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Early dementia diagnosis: blood proteins reveal at-risk people The results of a large-scale screening study could be used to develop blood tests to diagnose diseases such as Alzheimer’s before symptoms take hold.
M Naddaf, Nature, February 13, 2024
Genetic risk for attention-deficit/hyperactivity disorder predicts cognitive decline and development of Alzheimer's disease pathophysiology in cognitively unimpaired older adults.
Douglas T Leffa et al. Mol Psychiatry 2022 28(3) 1248-1255
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Assessment of Mendelian and risk factor genes in Alzheimer disease: a prospective nationwide clinical utility study and recommendations for genetic screening
G Nicolas et al, Genetics in Med, January 24, 2024
Advertisement by medical facilities as an opportunity route of APOE genetic testing in Japan: a website analysis.
Kenichiro Sato et al. J Community Genet 2024
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Interest in genetic susceptibility testing and disclosure of AD dementia risk in cognitively normal adults: a survey study.
Lisa Waterink et al. Alzheimers Res Ther 2024 16(1) 1
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Direct to Consumer Biomarker Testing for Alzheimer Disease—Are We Ready for the Insurance Consequences?
JJ Arias et al, JAMA Neurology, December 18, 2023
Attitudes toward pre-symptomatic screening for Alzheimer’s dementia in five European countries: a comparison of family members of people with Alzheimer’s dementia versus non-family members
IA Angelidou et al, Frontiers Genetics, December 2023
Organ aging signatures in the plasma proteome track health and disease.
Hamilton Se-Hwee Oh et al. Nature 2023 624(7990) 164-172
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APOE Genotype and Alzheimer Disease Risk Across Age, Sex, and Population Ancestry.
Michael E Belloy et al. JAMA Neurol 2023
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Pathway-specific polygenic scores for Alzheimer's disease are associated with changes in brain structure in younger and older adults.
Judith R Harrison et al. Brain Commun 2023 5(5) fcad229
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Consumers Can Now Buy a Blood Test to Evaluate Their Alzheimer Disease Risk, but Should They?
R Rubin, JAMA, September 13, 2023
Association of regular use of ibuprofen and paracetamol, genetic susceptibility, and new-onset dementia in the older population.
Yuanyuan Zhang et al. Gen Hosp Psychiatry 2023 84226-233
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Emerging diagnostics and therapeutics for Alzheimer disease.
Wade K Self et al. Nat Med 2023
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Cerebrospinal fluid proteomics define the natural history of autosomal dominant Alzheimer's disease.
Erik C B Johnson et al. Nat Med 2023
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Association of APOE ε4 Status With Long-term Declines in Odor Sensitivity, Odor Identification, and Cognition in Older US Adults.
Matthew S GoodSmith et al. Neurology 2023
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Proteomics analysis of plasma from middle-aged adults identifies protein markers of dementia risk in later life.
Keenan A Walker et al. Sci Transl Med 2023 15(705) eadf5681
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Mendelian randomization evidence for the causal effects of socio-economic inequality on human longevity among Europeans.
Chao-Jie Ye et al. Nat Hum Behav 2023
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Diagnostic Biomarkers of Amyloid and Tau Pathology in Alzheimer's Disease: An Overview of Tests for Clinical Practice in the United States and Europe.
L Iaccarino et al. J Prev Alzheimers Dis 2023 10(3) 426-442
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Outreach, Screening, and Randomization of APOE ε4 Carriers into an Alzheimer's Prevention Trial: A global Perspective from the API Generation Program.
T Walsh et al. J Prev Alzheimers Dis 2023 10(3) 453-463
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Shared genetic risk loci between Alzheimer's disease and related dementias, Parkinson's disease, and amyotrophic lateral sclerosis.
Michael Wainberg et al. Alzheimers Res Ther 2023 15(1) 113
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Modifiable cardiovascular risk factors and genetics for targeted prevention of dementia.
Ida Juul Rasmussen et al. Eur Heart J 2023
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Apolipoprotein E (APOE) Haplotypes in Healthy Subjects from Worldwide Macroareas: A Population Genetics Perspective for Cardiovascular Disease, Neurodegeneration, and Dementia.
Paolo Abondio et al. Curr Issues Mol Biol 2023 45(4) 2817-2831
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How one man's rare Alzheimer’s mutation delayed the onset of disease Genetic resilience found in a person predisposed to early-onset dementia could potentially lead to new treatments.
S Reardon, Nature, May 16, 2023
Demographic diversity of genetic databases used in Alzheimer's disease research.
Robert I Field et al. Hum Genet
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'It Totally Backfired': The Pitfalls of Alzheimer's Genetic Testing
J Steenhuysen, Medscape, April 24, 2023
Evaluation of Plasma Biomarkers for A/T/N Classification of Alzheimer Disease Among Adults of Caribbean Hispanic Ethnicity.
Lawrence S Honig et al. JAMA Netw Open 6(4) e238214
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Deep learning-based polygenic risk analysis for Alzheimer's disease prediction.
Xiaopu Zhou et al. Communications medicine 2023 3(1) 49
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Interaction analysis of ancestry-enriched variants with APOE-ɛ4 on MCI in the Study of Latinos-Investigation of Neurocognitive Aging.
Einat Granot-Hershkovitz et al. Scientific reports 2023 13(1) 5114
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Conquering Alzheimer's: a look at the therapies of the future Researchers are looking to drug combinations, vaccines and gene therapy as they forge the next generation of treatments for the condition.
A Abbot, Nature, April 4, 2023
The Effects of Subjective Cognitive Decline on APOE Genotype Disclosure in the Butler Hospital Alzheimer's Prevention Registry.
A K W Lee et al. The journal of prevention of Alzheimer's disease 2023 10(2) 152-161
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Page last reviewed:
Feb 1, 2024
Page last updated:
Apr 25, 2024
Content source:
Public Health Genomics Branch in the Division of Blood Disorders and Public Health Genomics
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National Center on Birth Defects and Developmental Disabilities
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